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Still, it is interesting that repeated APAP administration nonetheless correlated with worsened non-spatial memory performance to implicate the accelerated disruption of lateral entorhinal cortical inputs to the hippocampus 67

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doi: 10.1038/nature20117 17 GagnonEDuclosSRondeauCChevetECameronPHSteele-MortimerOet al

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This is most commonly associated with injury or repetitive or prolonged overload of the joint towards the end of its physiological range