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oxyphylla has numerous active ingredients with a wide range of pharmacological effects (Zhang et al., 2015)

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Abbreviations ARHL: Age-related hearing loss AC: Air conduction BC: Bone conduction WHO: World Health Organization TCM: Traditional Chinese medicine HCs: Hair cells OHCs: Outer hair cells IHCs: Inner hair cells SV: Stria vascularis EP: Endocochlear potential SL: Spiral ligament SGNs: Spiral ganglion neurons GWAS: Genome-wide association study ROS: Reactive oxygen species SOD2: Superoxide dismutase 2 TNF: Tumor necrosis factor IL-1: Interleukin 1 CAT: Catalase GPx: Glutathione peroxidase GR: Glutathione reductase GSH: Glutathione NAC: N-acetylcysteine NIHL: Noise-induced hearing loss Cyt-c: Cytochrome c JNK: C-Jun N-terminal kinase NGF: Nerve growth factor IGF-1: Insulin-like growth factor 1 THSG: 2,3,4,5-Tetrahydroxystilbene-2-O--D-glucoside HSP: Heat shock protein HO-1: Heme oxygenase-1 ABR: Auditory brainstem response SAMC: S-Allylmercaptocysteine DD: Diallyl disulfide SAC: S-Allylcysteine GB: Ginkgolide B References Chadha S, Kamenov K, Cieza A

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If there is presence of enzymatic activity and/or spontaneous oxidation in storage, we would expect to observe lower levels of total GSH and free GSH, and elevated levels of GSSG, in the EDTA-treated sample stored at 4 o C compared to the non-deproteinized EDTA-treated plasma stored at 80 o C

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A synergistic combination of niclosamide and doxorubicin as an efficacious therapy for all clinical subtypes of breast cancer

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