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In addition to such stoichiometric assessments of proteinprotein interactions, given that sphingolipid, as a saturated fatty acid, can organize a liquid-ordered domain by clustering (63, 69), cis -interaction between MHC-I and Ly49Q might incubate multivalent clusters of ITIMs within a limited membrane area

Oxidative stress is a central mechanism underlying the cardiotoxicity of many chemotherapy agents (Sterba 2013)