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10.1016/j.bbi.2011.04.006 127

10.1039/b311404j Nat

1-methyltheobromine 56

Iron deficiency (prevalent in 15% of adults) reduces monoamine oxidase activity, leading to 5-HT degradation and increased depressive symptoms

This suggests that the transformation process is independent of the estrogen receptor and is more probably due to the genotoxic effect of the estrogen metabolites [53]