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Another challenge to overcome for the next-generation nanomedicines resides in the regulatory classification, because the lack of knowledge regarding biosafety and long-term effects of nanomaterials leads to a regulatory uncertainty and deficient standards and protocols for scale-up manufacturing and safe clinical uses [678,679]

High glucose-induced accumulation of persistent peroxidation in cardiomyocytes triggers ferroptosis and results in cell damage in H9C2 cells and New Zealand rabbits

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