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This dilemma confronts policymakers and health care systems with competing, often undesirable trade-offs at the focal point of prevention, treatment, and long-term sustainability

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IGF-1 levels were elevated in our Japanese patients with schizophrenia who had a mean illness duration of 14.8 years, whereas IGF-1 levels were not altered in Turkish patients with schizophrenia who had a mean illness duration of 11.8 years 31 or Japanese patients with schizophrenia who had a mean illness duration of more than 10 years 33