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Microglia play a crucial role in orchestrating this phenotypic shift: upon activation, they release inflammatory mediators such as IL-1, TNF- and C1q, which induce a pro-inflammatory reactive astrocyte phenotype (often termed A1-like or neurotoxic reactive state) (Zhao et al., 2024

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GENEROSO, W.M., CAIN, K.T., KRISHNA, M., SHEN, C.W., & GRYDER, R.M

As a highly selective growth hormone secretagogue, ipamorelin stimulates the pituitary gland to increase growth hormone production without significantly impacting other hormones such as cortisol or prolactin

GHK-Cu (Glycine-Histidine-Lysine copper complex) is a naturally occurring human plasma tripeptide that binds Cu ions to form a biologically active complex