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TABLE 3 Examples of experimental strategies in aging-related research, which include gene editing technologies, mRNA-based therapies, stem cells (SCs) and extracellular vesicles (EVs) therapies and tissue engineering strategies

NAC specifically works on a protein that controls glutamate activity (the cystine/glutamate antiporter) resulting in reduced glutamate damage

The singlet oxygen in the aqueous environment can cross cellular membranes and diffuse over relatively long distances (150220 nm) (Manda et al

Optimization of NAMPT activators to achieve in vivo neuroprotective efficacy

Although SARS-CoV-2 was originally hypothesized to induce neurological symptoms, such as loss of smell and taste and altered consciousness, through direct infection of the brain, multiple case reports demonstrate little to no virus within the CNS compartment, including among patients that died due to severe disease (Schurink et al., 2020

Neurosci Lett 265:159162