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Arginine is then produced by ASL followed by hydrolysis by arginase 1 (Arg1) to urea and ornithine ( Figure 1 ) ( 2.2 Cancer and immune cells have high demands for arginine Arginine is conditionally essential in patients with severe trauma, compromised immune system, or cancer cachexia

However, the emergence of apatinib resistance has significantly limited its clinical application

2019) are expressed in murine astrocytes and contribute to the remarkable ability of these brain cells to efficiently detoxify applied peroxides with halftimes in the minute range (Dringen and Hamprecht 1997

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A noncanonical function of EIF4E limits ALDH1B1 activity and increases susceptibility to ferroptosis

After which cysteinylglycine can further be processed to produce intracellular cysteine