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cruzi forms called trypomastigotes enter the bloodstream and invade various host cells

In our study, we examined the heartbeat of 4-dpf F1 transgenic fish larvae carrying either LMNA (WT) or LMNA mutants

Several hypotheses suggest that TMAO may contribute to heart disease by disrupting the intestinal barrier, inducing chronic inflammation, promoting oxidative stress, impairing mitochondrial function, and increasing hypercoagulability

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It is also important to note that the increase in efficacy of the drug regimen did not correlate with any increase in toxicity to healthy tissues (Murphy 2011)

Sims NR, Muyderman H