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During the early stages of iron overload, a significant amount of released iron is transported to the mitochondria as a buffer, and mitophagy may segregate iron into the mitophagosomes and decrease the origin of ROS for ferroptosis [65, 66]

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Studies from the German-speaking Region: Key Substance for Detoxification Promotes Immune Defense (Luxembourg Institute of Health) Research by Prof

Cell Mol Immunol 23 , 743772 (2026)

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Overall, this ROS-induced autophagy serves as a crucial response to oxidative stress, enabling cells to adapt to adverse conditions and enhance survival