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The pericytes of the BBB have contractile proteins that help in restricting the breadth of blood channels in order to regulate the passage of materials via the BBB

Setting a daily alarm or associating injection with another routine behavior improves adherence

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Materials and methods Drugs and chemicals Powdered L-PAM and BSO (DL buthionine-( S,R )-sulfoximine) were purchased from Sigma-Aldrich (St Louis, MO, USA) and clinical grade BSO (L-buthionine ( S,R )-sulfoximine (50 mg/ml)) was provided by the National Cancer Institute (Bethesda, MD, USA)