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The SC and M404 series also face solubility and bioavailability issues

In astrocytes, GlyT1 is the most important glycine transporter and is important for regulating glycine levels at inhibitory and excitatory synapses that are essential for neurotransmission mediated by NMDA and GlyR receptors (LpezCorcuera et al

[DOI] [PMC free article] [PubMed] [Google Scholar] 52.Hoffman TE et al

Additionally, neither GshF nor mito-GshF expression was sufficient to rescue superoxide dismutase ( Sod1 ) depletion or defects in iron sulfur cluster biosynthesis resulting from cysteine desulfurase ( Nfs1 ) knockout (Fig