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ATP13A2 is a P type ATPase generally found in the membranes of acidic vesicles in neurons which, along with the other two more common class of Zinc transporters belonging to the ZnT (SLC30) and ZIP (SLC39) families, is entrusted to serve exactly this role (van Veen et al., 2014)

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0.2 mol/L pH 7.8 phosphate buffer and the proxy matrix containing 0.9% NaCl in 10 mmol/L phosphate buffer, pH 7.8 were prepared once a week and kept at 4 C

Studies have documented its effects on the hypothalamic-pituitary-adrenal (HPA) axis and its ability to stabilise enkephalins in blood serum, contributing to its anxiolytic mechanism of action

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Mechanistically, Oteseconazole, like other triazoles, inhibits 14-demethylase in the fungal cytochrome P450 system, thereby disrupting ergosterol biosynthesis, an essential component of fungal cell membranes (Hoy, 2022)