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Excessive production of RAGE on brain microvascular endothelial cells increases A transport into the brain tissue and decreases its removal, leading to the accumulation of A in the brain tissue, which in turn triggers a series of neurodegenerative pathological changes, such as the formation of amyloid plaques, the formation of neurofibrillary tangles, and the loss of neurons (23)

Mid estimate assumes 30%

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For example, berberine and palmatine have been reported can exert various pharmacological activities, such as anti-inflammatory, chondroprotective, and neuroprotective properties (Singh et al., 2019

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Hold for 30 seconds and repeat two to three times per side