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In addition, melittin has been found to encourage TRAIL-resistant HCC cells to TRAIL-induced cell death, probably through stimulating the CAMKII-TAK1-JNK/p38 route and blocking the IKK-NFB signaling

Positively or negatively charged drugs interact differently with the endothelial glycocalyx and may also show different binding characteristics or transporter affinities if the glycocalyx is altered in PD [47, 49, 308]