glutathione dhea Synaptamide (N-Docosahexaenoyl ethanolamine (DHEA)) |

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Placebo Group The level of CoQ10 increased slightly, and the increase was significant

Evaluation: Body fat (DXA scanning) Lean mass Insulin sensitivity Energy expenditure What they found: The combination showed an additive effect on fat reduction vs monotherapy AOD-9604 partially protected lean mass during GLP-1-induced weight reduction Increased energy expenditure in combination (~3 % vs GLP-1 alone) No new safety signals Why it matters: It validates the concept of combination , the idea that AOD-9604 may not work on its own, but can add value in combination with incretin agonists

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GLP-1 agonists are highly regulated, FDA-approved prescription medications with defined dosing protocols and monitored side-effect profiles