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Pathological Consequences of OS in Diabetes Reactive oxygen species are generated under physiological conditions and are involved to some extent as signaling molecules and defense mechanisms as seen in phagocytosis, neutrophil function and shear-stress induced vasorelaxation, excessive generation of ROS has pathological consequences including damage to proteins, lipids and DNA (Boullier et al ., 2001)

B12 is fundamental to a number of important metabolic processes, including: Red blood cell formation Nervous system function Nutrient absorption Adrenal gland support Cognitive function and memory Brain cell regeneration DNA synthesis Mitochondrial metabolism Male and female reproductive health Because of its important role in the nervous system, severe B12 depletion over time can lead to irreversible neurological damage

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