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Magnesium deficiency in the brain leads to platelet aggregation and the release of glutamate, resulting in the formation of 5-hydroxytryptamine (5-HT)

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doi: 10.1111/sji.12998 14

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49 Moreover, it appears that ketamine or its metabolites induces microvascular changes in the bladder and possibly the kidney, causing an autoimmune reaction against the bladder urothelium and submucosa