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Die erste pilotierte IV-Anwendung an gesunden Erwachsenen (Lee & Burgess 2025, PMID 40131143) untersuchte zwei Probanden mit IV-Dosen bis zu 20 Milligramm und dokumentierte keine Nebenwirkungen eine ermutigende, aber statistisch wenig aussagekrftige Sicherheits-Information

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while one small cohort showed improvements in EDS and physical activity [94], other studies failed to demonstrate efficacy [132, 134], possibly due to preserved endogenous melatonin secretion [132]