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Similar inferences can be made based on the findings from some earlier clinical studies and investigations in nonrodent models.33, 34 In a study using Beagle dogs, the administration of hepatic stimulatory substance alone or in combination with TGF- (an EGFR ligand), insulin-like growth factor II, and insulin did not affect survival or liver regeneration after a lethal dose of APAP

Nagai R, Shirakawa J, Ohno R, et al

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c-Myc also influences glutamine metabolism indirectly by modulating the expression of miR-15a and miR-16 (49, 50)

For sham operations, the surgery was performed only to expose the L5 spinal nerve or tibial nerve but without ligation and crush