Importantly, the enzymatic activity of TETs is regulated by 2-oxoglutarate (2OG) as a cofactor and suppressed by metabolites such as 2-hydroxyglutarate (2HG) as a competitor of 2OG
MSH2 mutation rate is the highest, while the MLH1 mutation is the second most frequent in LS-related EC as well as in LS-related CRCs
In addition, AIMPs also participate in a spectrum of biological processes, including immune regulation, nervous system functions, angiogenesis, and genome stability, which are considered unexpected because AIMPs are classified as housekeeping proteins
doi: 10.3390/nu11030681
This bioactivity stems from multi-target mechanisms: significant suppression of key pro-inflammatory factors (TNF-, IL-1, IL-6, and iNOS) synthesis/release, enhanced antioxidant capacity ( P 0.05) and showed no significant difference in hepatic TG accumulation versus controls, collectively confirming BSPs metabolic safety and minimal hepatotoxic potential at these doses (He et al., 2025)
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