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However, the most effective method is to closely follow a testing routine in defined intervals (monthly/quarterly) and strictly quarantine cell lines introduced to the lab until tested negatively

This will lead to more stable levels and less E2 spikes, ergo fewer overall issues

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Koperska, A., Wesoek, A., Moszak, M., & Szuliska, M

Unlike unicellular organisms, which do not form firm attachments between adjacent cells, mammalian cells form membrane attachments to facilitate a variety of functions such as small molecule diffusion and barrier formation 179

Nutrients 10 , 350 (2018)