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Post-translational modifications: host expression systems determine post-translational processing (e.g., glycosylation) required for correct folding and epitope preservation

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(2012) noted reduced glycine and GABA expression in auditory midbrain structures with age, accompanied by altered expression of their receptors

Conclusions and future directions The lack of positive effects from CM supplementation within the existing literature is due to a number of factors, including the testing protocols not featuring a predominantly aerobic energy contribution, the lack of testretest reliability of exercise protocols, dosing strategy (i.e., amount and timing), and the recent discovery of quality control issues with some manufacturers stated citrulline:malate ratios

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Despite these challenges, in vivo models remain crucial tools in PNI research [89]