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Or, more specifically, how one of these enzymes starts to fail with age or persistent illness

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After thawing, exposure to oxygen in the environment accelerates the generation of ROS, and antioxidant systems (such as the superoxide dismutase capacity in seminal plasma and sperm cells) cannot keep up with the rate of accumulation of hydroxyl and superoxide radicals [7]

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Berberine Attenuates Ischemia-Reperfusion Injury through Inhibiting HMGB1 Release and NF-b Nuclear Translocation