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It is questionable whether a certain target is universally effective in all HNSCC patients

Retatrutides glucagon receptor activity may increase energy expenditure and influence fat metabolism, although it can also affect heart rate and gastrointestinal tolerance in some individuals

doi: 10.1016/j.neubiorev.2013.08.004 139

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This suggests that hyperthermia selectively targets leukemic cells more effectively than normal hematopoietic cells, and serums protective role is not sufficient to alter this outcome