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Additionally, chronic inflammation caused by exposure to environmental toxins leads to autoimmune conditions

( 20:1103 ) Li S, Yang C, Wang W et al (2024) First-in-human study to assess the safety, tolerability, and pharmacokinetics of intravenous SHPL-49 following single- and multiple-ascending-dose administration in healthy adults

On the other hand, CaSR accelerated apoptosis and synaptic plasticity deficit by upregulating protein kinase C (PKC) and extracellular signal-regulated kinases 1/2 (ERK1/2) [49]