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Additionally, AMPK induces nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2), upregulating antioxidant enzymes such as glutathione peroxidase (GPX), thereby mitigating oxidative stress injury

The enterocyte lining of the GI tract contains one of the most rapidly reproducing cells of the human body, and depletion of this protein can result in continued disruption of intestinal integrity

In addition to GLUTs, sodium-glucose transporters (SGLTs) are also expressed in many cancers 61

21 The focus of this review is to outline therapeutic strategies that have previously been developed and tested, agents that are currently being tested in clinical trials and future therapies that extrapolate from the latest published basic research in the laboratory for the treatment of the most common NF1-related tumours, including cNFs, pNFs, MPNSTs and OPGs