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When their seminal research was published in *Cell* in March 2017, it introduced the first precision senolytic peptide capable of selectively eliminating senescent cells while sparing healthy tissue, opening unprecedented opportunities for studying aging mechanisms and developing research tools for age-related cellular dysfunction

doi: 10.4269/ajtmh.1999.60.487 89 CurwenRSAshtonPDSundaralingamSWilsonRA

In addition, the introduction of hydroxyl groups at C-20 decreased the inhibitory potency against HeLa cell lines, while the presence of acetoxy groups at C-18 seemed to enhance the cytotoxic activity (Zhang J