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Description

Blocking the insulin/IGF signaling cascade reduces the susceptibility of cells to excitotoxic necrosis [125]

No adverse hormonal effects were observed at any tested dose

Lysosomal acidification mechanisms

& Rupp, J

Proliferation of released mouse and human CD8 + T cells was modestly reduced (1.5-fold and 1.2-fold, respectively), whereas non-arrested cells were more sensitive to mTOR inhibition, showing 3.4-fold and 7.8-fold reductions, respectively (Fig