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These condensates subsequently translocate into the nucleus and target long-chain acyl CoA synthetase 4 (ACSL4) and promote its expression level, which enhances PUFA (a key step in ferroptosis execution [98]) peroxidation by ACSL4, ultimately activating ferroptosis [97]

Applying the airbrakes: treating mitochondrial disease with hypoxia

R., Nguyen, D

10.1021/acs.nanolett.8b00856 84 YaN.ZhangD.WangY.ZhengY.YangM.WuH.et al (2024)

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And taking a fish oil supplement is probably the only way theyre going to get adequate amounts of these critical fatty acids