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& Heemann, U

Complex I inhibition triggers a transient reduction of ATP levels and promotes the production of ROS and reactive nitrogen species (RNS), leading to cell death [94,95,96,97]

Complementary data from the World Health Organization (WHO) demonstrate that DM rose from the 11th leading cause of death in 2002 to 8th leading cause in 2012, with current projections indicating its ascension to 7th position by 2030 [10, 11], demonstrating the growing burden of DM across both morbidity and mortality parameters

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Mitochondria are the main producers for ROS

For example, the NF-B-mediated inflammatory response is crucial in liver IRI, and the autopolyubiquitination of K63-linked tumor necrosis factor receptor-associated factor 6 is essential for NF-B activation