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The ideal adaptogen should minimize the negative effects of stress, perform safely and beneficially even when administered in doses greater than necessary, and be devoid of undesirable side effects, such as not impairing bodily functions beyond what is necessary [64]

The second controversial disease is Keshan disease

McDermott, M

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Aberrant cell cycle progression leads to chromosomal abnormalities and embryonic arrest, making cell cycle regulation biomarkers important predictors of embryo competence [395]

Effects of supplementation with main coffee components including caffeine and/or chlorogenic acid on hepatic, metabolic, and inflammatory indices in patients with non-alcoholic fatty liver disease and type 2 diabetes: a randomized, double-blind, placebo-controlled, clinical trial