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Moreover, it promotes degeneration of epithelial cells of the proximal convoluted tubule and tubular cylinders, enhances focal mineralization, damages podocytes of the Bowman's capsule, increases serum levels of urea and creatinine, and brings about histological changes in kidney tubules ( Figure 4 ) [77,84]

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Empty pTRV2 vector was used as a control

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doi:10.1093/nar/gks891

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