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The endothelium (the lining of our blood vessels) is arguably the largest endocrine organ in the body

Assiut Vet Med J 70(183):267275 Izuddin WI, Humam AM, Loh TC, Foo HL, Samsudin AA (2020) Dietary postbiotic Lactobacillus plantarum improves serum and ruminal antioxidant activity and upregulates hepatic antioxidant enzymes and ruminal barrier function in post-weaning lambs

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In fact, when cytokine receptors, pattern recognition receptors, or T- and B-cell receptors are activated, the IB kinase (IKK) complex is stimulated, resulting in IB phosphorylation and degradation