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Importantly, inflammation increases with age (inflammaging), which may help explain the high rates of treatment resistance observed in this population [275]

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To assess the effect of acidic pH, Syn WT was buffer-exchanged into 20 mM sodium acetate buffer pH 4.0 before Th-T addition

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Balza E, Castellani P, Delfino L, Truini M, Rubartelli A