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Hereditary spastic paraplegias is a highly heterogeneous autosomal recessive hereditary disease most commonly caused by mutations in SPG11 and SPG15 124

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The GLP-1 companion supplement guide covers recommended additions during therapy, including magnesium (for constipation), electrolytes (for hydration), and additional protein supplementation

In contrast, in cachectic tumor-bearing mice, the light chain 3 beta II/I (LC3BII/I) ratio, a marker of autophagy activation, was elevated in TSV mice but significantly reduced in TER mice, indicating that the combination therapy reduced muscle degradation processes (88)

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