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Rotate sites systematically (abdomen, thighs, upper arms) to avoid lipohypertrophy [9]

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Although more studies are needed to provide a conclusive effect of GLP-1 receptor agonists on peripheral neuropathy, studies have shown that among participants with type 2 diabetes mellitus receiving exenatide treatment, a significant increase in corneal nerve branch density ( p = 0.02) and vibration perception threshold was observed [52]

Post-Market Surveillance Gap: Because AOD-9604 never received FDA approval for any indication, there is no post-market surveillance system capturing safety signals from widespread clinical use