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Description

J Thromb Haemost 14:551558

In ovarian cancer, C-MYC was shown to directly bind and downregulate NCOA4 mRNA, thereby inhibiting ferritin autophagy and ferroptosis, reducing ROS production, blocking mitophagy, and finally promoting tumor proliferation, invasion, immune evasion, and tumorigenesis through suppression of HMGB1 release (183)