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Abnormal microglial activation, oxidative stress, and neuronal death are also associated with the progression of the disease

Lekshmi Sheela, D., Nazeem, P

NET formation and the neutrophil respiratory burst are regulated by metabolic mechanisms downstream of extracellular inflammatory signals 31,32,33,34,35,36,37,38,39,40

Furthermore, multiple treatments developed to relieve symptoms and to modify the underlying disease in CIPN have failed

PDEVs inhibit skin aging Studies have shown that EVs secreted by young cells alleviate cellular senescence in aged organisms by reducing oxidative stress and lipid peroxidation [78]

Due to the close relationship between the gut and liver, altering the gut microbiome can affect liver functions