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Medical therapies are an important treatment option, particularly for patients who may not be suitable for surgery or those with persistently high levels of GH/IGF1 following surgery

In TKM and TCM, such analyses have clarified the roles of specific herbs in modulating neuroinflammatory and redox-related signaling pathways

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However, their unsatisfactory therapeutic efficacy due to poor skin penetration, transient therapeutic effects, and risks of cutaneous atrophy or tachyphylaxis with prolonged use has constrained their clinical applications [3, 4]

It can cause some local side effects (irritation, itching) and must be used long-term to maintain its effectiveness