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This ligation is formed via amide bond formation of lactamization

In contrast, some oncogenic drivers could allow cancer cells to bypass the need for glutamine by upregulating other metabolic pathways for their cellular growth and proliferation

Fenske DB

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Our data showed that ARPs could promote autophagy by transcriptionally activating autophagy-related genes, which indicated that ARPs may ameliorate APAP-induced liver injury by restoring autophagy (Figure 10E)