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Similar to IDH2, Mn-SOD could be deacetylated and potentiated by SIRT3

Treatment of mice with sodium butyrate (a bacterial SCFA) alleviates neuroinflammation in models of AD and MS by dampening microglial activation and promoting an anti-inflammatory milieu [71]

But ultimately, the results are pretty skewed

Abbreviations SLE: Systemic lupus erythematosus NW: Normal-weight EBW: Excess body weight DMCpGs: Differentially methylated CpG sites SAT: Subcutaneous adipose tissue CRP: C-reactive protein LDL-c: Low-density lipoprotein cholesterol HDL-c: High-density lipoprotein cholesterol IL-6: Interleukin-6 TNF-: Tumor necrosis factor alpha SLEDAI: Systemic lupus erythematosus disease activity index BMI: Body mass index CONSORT: Consolidated standards of reporting trials GEE: Generalized estimating equation IPAQ: International physical activity questionnaire TEI: Total energy intake SAM: S-adenosylmethionine THF: Tetrahydrofolate MTHFR: Methylenetetrahydrofolate reductase GO: Gene ontology KEGG: Kyoto encyclopedia of genes and genomes GSA: Gene-set analysis DMRs: Differentially methylated regions NES: Normalized enrichment scores GSEA: Gene set enrichment analysis ITT: Intention-to-treat SPSS: Statistical package for the social sciences References Tian J, Zhang D, Yao X, Huang Y, Lu Q

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