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The evidence suggests a threshold effect rather than a linear dose-response curve

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As internal controls, the expression levels of HDGF mRNA in EBC-1 cells cultured with or without FBS were normalised to corresponding expression levels of GAPDH mRNA, and those of HDGF, VEGF-A, BDNF, FGF-2 and FGF-5 mRNAs in the NSCLC cell lines were normalised to the corresponding expression levels of 18S-rRNA

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This is sometimes cited as proof of safety

Effect of decellularization parameters on the efficient production of kidney bioscaffolds