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In recent years, extensive research (Figure 2) has shown that TMAO can activate the inflammasome NOD-like receptor protein 3 (Nlrp3) through different pathways to activate the inflammatory signal pathway, resulting in aggravation of oxidative stress and, in turn, of endothelial dysfunction

They catalyze the nucleophilic attack of reduced glutathione (GSH) on the electrophilic centers of these molecules

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This little diagram sums it up nicelyits a simple path from a solid powder to a solution you can actually use

Depending on the cellular and physiological milieu, TQ can undergo both enzymatic and non-enzymatic redox reactions to generate either pro-oxidants (semiquinone) or antioxidants (thymohydroquinone)