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The symptoms of PCD range widely, from metabolic decompensation in infancy to asymptomatic manifestations in adulthood

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For example, the p28 receptor, a thyroid hormone receptor located in the IMM, binds thyroid hormone (T3) with high affinity [81, 82], prompting mitochondria to adjust mtDNA transcription or modulate mRNA and rRNA ratios [83, 84]

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The genetic heritage largely determines the age at which gray hair first appears