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2 Mechanisms of ferroptosis 2.1 Disruptions in iron metabolism Under physiological conditions, systemic iron homeostasis is maintained through coordinated dietary absorption and macrophage-mediated recycling of senescent erythrocytes (Vogt et al., 2021)

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However, the less stable and untreated U597S and Y296A variants had a ratio of 1112, suggesting there is contaminating apo-enzyme in these samples

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Genet Mol Res (2010) 9:62028

This is especially true with regards to NK (natural killer) T cells