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We now demonstrate that targeting CD38 with heavy-chain antibodies that selectively inhibit NAD glycohydrolase activity without inducing cell death or global CD38 blockade will boost tissue NAD + and precursor levels and sirtuin activity, reduce cellular senescence and mitigate fibrosis and inflammation in multiple organs

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Conflict of interest Authors RE and JB were employed by the company Great Ormond Street Hospital for Children NHS Foundation Trust

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