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Weight loss can also influence thyroid hormone levels

Most of the GCL holoenzyme can be reversibly dissociated by treatment with dithiothreitol [42], while oxidative stress may enhance holoenzyme formation as it increases GCL activity in the absence of any change in the expression of GCL subunits [45]

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The Phase 1 clinical study of VIT-2763 demonstrated that serum iron levels and transferrin saturation declined transiently, and no obvious safety concerns were identified ( Targeting the hepcidin-ferroportin axis offers a novel therapeutic direction for patients with -thalassemia, particularly for those with NTDT, as it not only reduces iron overload but also improves anemia, decreases ineffective erythropoiesis, and alleviates splenomegaly

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