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However, the OS benefit is questioned by some experts because of deaths unrelated to treatment or disease and because 31 % of FCR patients did not complete all six treatment cycles

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doi: 10.1002/art.24751 40 UrregoTOrtiz-ReyesBVanegas-GarciaALMunozCHGonzalezLAVasquezGet al

Despite their efficacy, long-term LD use is associated with motor complications, prompting the development of novel therapies such as adenosine A2A antagonists (istradefylline), which reduce OFF episodes, and GLP-1RAs, which show neuroprotective potential

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